Our technology
The Nacamed technology is based on innovative and proprietary nanoparticles that can improve the delivery of medicines. The aim is to maximize medical effects while minimizing side-effects by using our silicon-based drug delivery platform. This includes the delivery of small molecules as well as biopharmaceutics.
In addition to improved drug delivery by controlling drug release, the advantages of our technology include precise control of the particle synthesis using a unique bottom-up technology with various control parameters to produce particles with the desired properties.
Focus on delivery - based on our Nacamed particles:
Delivery of poorly soluble drugs
Poor solubility is considered one of the major challenges in drug development. 40% of drugs on the market and 90% of drugs under development have insufficient water solubility1. This can lead to poor oral bioavailability, high dosing, high cost, gastrointestinal side effects, drug interactions and potential environmental problems.
The Nacamed particles can capture and stabilize a crystal form of these drugs with faster dissolution upon oral delivery, that will improve the uptake of the drug. This will result in improved dose responses, reduced side effects and lowered costs.
Production of H2 in the body from silicium nanoparticles
Hydrogen gas has shown to have several therapeutic effects in many different disease states. As an antioxidant hydrogen can reduce the amount of oxidative stress in addition to possessing several other homeostasis-promoting mechanisms. Hydrogen therapy has shown positive indications in clinical trials in the treatment of cardiovascular diseases, cancer, respiratory diseases, central nervous system disorders, infections and many more. The available hydrogen administration methods are limited due to the poor water solubility and the explosive hazard when mixed with oxygen. Administration of an oral formulation containing the Nacamed particles offers a feasible way to safely and efficiently deliver large doses of hydrogen for disease treatment.
Science: Production of hygrogen in vivo
Porous nano silicium and the function of hydrogen in vivo- Checking out the science and landscape
Research summary:
Medical use of hydrogen gas (H2) has been given increasing attention over the past 15 years with numerous clinical trials for a variety of indications. The biological activity of H2 includes antioxidant properties and thereby the ability to neutralize damaging reactive oxygen species (ROS). Administration of hydrogen as a medical gas is limited by the poor water solubility and by the flammability of H2 in air. Therefore, nanocarriers have been investigated for safer and more efficient administration of hydrogen. Silicon particles are suggested for oral administration with the ability to undergo a redox reaction with water to produce H2 in vivo.
Research article by Hennie Marie Johnsen, PhD student and project technician, Nacamed.
TECHNOLOGY BENEFITS
The Nacamed’s drug delivery technology has multiple competitive advantages over other alternative delivery technologies
SAFETY
Nacamed´s nanoparticle is a natural, endogenous component of the body
Fully biocompatible and non-toxic in living tissue
Nacamed´s nanoparticle has a simple metabolism – in vivo it generates hydrogen in a safe way
Nacamed´s nanoparticle has been recognized by matitilsynet….. Jo and Marie input as a GRAS material (Generally Regarded As Safe)/ look at Japan
VERSATILITY
Suitable for small molecules, biomolecules
Suitable for highly water soluble and poorly water soluble compounds
Administration in various dosage forms: microparticles, tablets and depot injections ?
CONTROLLED RELEASE
Nacamed´s nanoparticle is fully biodegradable by dissolution in body fluids
Drug release strictly controlled by silica surface erosion
Nacamed´s nanoparticle dissolution can be adjusted from min to hours and days??? Jo to verify
Initial burst well controlled
Our partners and colloborators
Nacamed partners with top-tier research institutions and pharmaceutical companies
