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Porous silicon nanoparticles for nanomedicine: preparation and biomedical applications

Hélder A Santos, Ermei Mäkilä, Anu J Airaksinen, Luis M Bimbo & Jouni Hirvonen
Research summary:

The research on porous silicon (PSi) materials for biomedical  applications has expanded greatly since the early studies of Leigh Canham  more than 25 years ago. Currently, PSi nanoparticles are receiving growing attention from the  scientific biomedical community. These nanostructured materials have emerged  as promising multifunctional and versatile platforms for nanomedicine in drug  delivery, diagnostics and therapy. The outstanding properties of PSi,  including excellent in vivo biocompatibility and biodegradability, have led  to many applications of PSi for delivery of therapeutic agents. In this  review, we highlight current advances and recent efforts on PSi nanoparticles  regarding the production properties, efficient drug delivery, multidrug delivery,  permeation across biological barriers, biosafety and in vivo tracking for  biomedical applications. The constant boost on successful preclinical in vivo  data reported so far makes this the ‘golden age’ for PSi, which is expected  to finally be translated into the clinic in the near future.

Santos et al. Nanomedicine (2014) 9(4), 535–554
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